AvĐÔ°ź

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  4. Madeleine RĂ„dinger

Madeleine RĂ„dinger

Avd-/Sektionschef, bitr, inst

Department of Internal Medicine and Clinical Nutrition
Telephone
+46 31-786 67 13
Mail
madeleine.radinger@lungall.gu.se
Visiting address
Medicinaregatan 1F
413 90 Göteborg
Postal address
Box 424
405 30 Göteborg

Professor

Institute of Medicine
Telephone
+46 31-786 67 13
Mail
madeleine.radinger@lungall.gu.se

About Madeleine RĂ„dinger

Title: PhD, Associate professor Position: Senior Lecturer, Chairman of Krefting Research Centre

Madeleine RĂ„dinger graduatedfrom the University AvĐÔ°ź with an MSc degree in Molecular biology, and in2006 she received a PhD in Respiratory Medicine and Allergologyat the University AvĐÔ°ź. After her PhD, she took on a 2.5 years postdoctoral position at the Laboratory of Allergic Diseases, National Institute of Allergic and Infection Diseases, the National Institute of Health (NIH), in Bethesda, USA. She returned to the University AvĐÔ°ź in 2010 and in 2013, she became Associate professorin Immunology.

Research

RĂ„dinger research focuses on increasing the understanding of the immune systemin subgroups of asthma, including the contribution of immune regulatory microRNAs. The ultimate goal is to identify molecular drivers linked to clinical features in asthma subgroups, for stratification for targeted therapy, diagnosis and potentially identification of new therapeutic targets.

Her research is funded by the , the Swedish Research Council, the Swedish Heart and Lung foundation, the Swedish Foundation for Strategic Research and ALF.

RĂ„dinger collaborates with several national and internationalm research groups studyingmimmunology, respiratory research and microRNA biology. In 2019, she was awarded the big grant from the Swedish association for allergy research (SFFA) and the Swedish Cancer-and Allergy Foundation environmental medical award for her research.

Group members

  • Elisabeth Ax– Industrial PhD student together with AstraZeneca
  • – PhD student
  • – PhD/laboratory engineer
  • – postdoctoral research fellow
  • – postdoctoral research fellow

Articles

Key publications

1. MalmhÀll C, Alawieh S, Lu Y, Sjöstrand M, Bossios A, Eldh M and RÄdinger M. 2014. MicroRNA-155 is essential for TH2 mediated allergen-induced eosinophilic inflammation in the lung. J Allergy Clin Immuol.2014 May;133(5):1429-38. This is the first study to describe a role for microRNA-155 in the regulation of type 2 mediated allergic eosinophilic inflammation in a mouse model of asthma.

2.Johansson K, MalmhÀll C, Ramos-Ramirez P and RÄdinger M.2017.MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation. J Allergy Clin Immunol.2017 Mar;139(3):1007-1016. This is the first study to describe aregulatoryrole for a microRNAin ILC2 functionality.

3.MalmhÀll C, Weidner J, RÄdinger M. 2019. MicroRNA-155 expression suggests a sexdisparity in innate lymphoid cells at the single-cell level.Cell Mol Immunol.2019 Oct 10. doi: 10.1038/s41423-019-0303-4. This is the first study to describethat human circulating ILCs express microRNA-155 and that this expression is higher in females.